Heterocyclic Building Blocks-Cinnoline

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Pharmazie called Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives, Author is Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W., which mentions a compound: 137195-33-6, SMILESS is O=C1CNNC2=C1C=CC=C2.[H]Cl, Molecular C8H9ClN2O, Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

There is still a lot of research devoted to this compound(SMILES：O=C1CNNC2=C1C=CC=C2.[H]Cl)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, and with the development of science, more effects of this compound(137195-33-6) can be discovered.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan published the article 《Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline》. Keywords: cinnolone tetrahydro haloacyl derivative.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).COA of Formula: C8H9ClN2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

There is still a lot of research devoted to this compound(SMILES：O=C1CNNC2=C1C=CC=C2.[H]Cl)COA of Formula: C8H9ClN2O, and with the development of science, more effects of this compound(137195-33-6) can be discovered.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 137195-33-6, is researched, SMILESS is O=C1CNNC2=C1C=CC=C2.[H]Cl, Molecular C8H9ClN2OJournal, Acta Poloniae Pharmaceutica called Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides, Author is Groszkowski, Stefan; Stanczak, Andrzej, the main research direction is oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro.Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

There is still a lot of research devoted to this compound(SMILES：O=C1CNNC2=C1C=CC=C2.[H]Cl)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, and with the development of science, more effects of this compound(137195-33-6) can be discovered.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

COA of Formula: C8H9ClN2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides. Author is Groszkowski, Stefan; Stanczak, Andrzej.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

There is still a lot of research devoted to this compound(SMILES：O=C1CNNC2=C1C=CC=C2.[H]Cl)COA of Formula: C8H9ClN2O, and with the development of science, more effects of this compound(137195-33-6) can be discovered.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till researched the compound: 5-Fluoro-2-methylpyrimidin-4-amine( cas:1416372-67-2 ).Safety of 5-Fluoro-2-methylpyrimidin-4-amine.They published the article 《Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt》 about this compound( cas:1416372-67-2 ) in Beilstein Journal of Organic Chemistry. Keywords: amino fluoropyrimidine preparation; amidine hydrochloride potassium cyano fluoroethenolate cyclization; fluoropyrazole amino preparation; hydrazine potassium cyano fluoroethenolate cyclization; cyclization; fluorinated heterocycles; fluorine; pyrazoles; pyrimidines. We’ll tell you more about this compound (cas:1416372-67-2).

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

If you want to learn more about this compound(5-Fluoro-2-methylpyrimidin-4-amine)Safety of 5-Fluoro-2-methylpyrimidin-4-amine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1416372-67-2).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives, published in 1994-06-30, which mentions a compound: 137195-33-6, Name is 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, Molecular C8H9ClN2O, Formula: C8H9ClN2O.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

If you want to learn more about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Formula: C8H9ClN2O, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Related Products of 1416372-67-2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Fluoro-2-methylpyrimidin-4-amine, is researched, Molecular C5H6FN3, CAS is 1416372-67-2, about Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt. Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till.

A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

If you want to learn more about this compound(5-Fluoro-2-methylpyrimidin-4-amine)Related Products of 1416372-67-2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1416372-67-2).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

COA of Formula: C8H9ClN2O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

If you want to learn more about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)COA of Formula: C8H9ClN2O, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Computed Properties of C8H9ClN2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides. Author is Groszkowski, Stefan; Stanczak, Andrzej.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

If you want to learn more about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Computed Properties of C8H9ClN2O, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. published an article about the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6,SMILESS:O=C1CNNC2=C1C=CC=C2.[H]Cl ).Reference of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:137195-33-6) through the article.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

If you want to learn more about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Reference of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics