Category: cinnoline

Related Products of 137195-33-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline. Author is Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Groszkowski, Stefan; Stanczak, Andrzej published the article 《Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides》. Keywords: oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Recommanded Product: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 137195-33-6, is researched, SMILESS is O=C1CNNC2=C1C=CC=C2.[H]Cl, Molecular C8H9ClN2OJournal, Article, Pharmazie called Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives, Author is Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W., the main research direction is central nervous system cinnoline derivative preparation.Application of 137195-33-6.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

SDS of cas: 137195-33-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides. Author is Groszkowski, Stefan; Stanczak, Andrzej.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 137195-33-6, is researched, Molecular C8H9ClN2O, about Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline, the main research direction is cinnolone tetrahydro haloacyl derivative.Synthetic Route of C8H9ClN2O.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ) is researched.Application of 137195-33-6.Groszkowski, Stefan; Stanczak, Andrzej published the article 《Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides》 about this compound( cas:137195-33-6 ) in Acta Poloniae Pharmaceutica. Keywords: oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro. Let’s learn more about this compound (cas:137195-33-6).

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan published the article 《Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline》. Keywords: cinnolone tetrahydro haloacyl derivative.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.They published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 about this compound( cas:137195-33-6 ) in Pharmazie. Keywords: central nervous system cinnoline derivative preparation. We’ll tell you more about this compound (cas:137195-33-6).

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride(SMILESS: O=C1CNNC2=C1C=CC=C2.[H]Cl,cas:137195-33-6) is researched.Electric Literature of C8H12ClNO2. The article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 in relation to this compound, is published in Pharmazie. Let’s take a look at the latest research on this compound (cas:137195-33-6).

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride(SMILESS: O=C1CNNC2=C1C=CC=C2.[H]Cl,cas:137195-33-6) is researched.SDS of cas: 17927-65-0. The article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 in relation to this compound, is published in Pharmazie. Let’s take a look at the latest research on this compound (cas:137195-33-6).

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

Compound(137195-33-6)Related Products of 137195-33-6 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride), if you are interested, you can check out my other related articles.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics