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New efficient method for the synthesis of chiral 2,2?-bipyridyl ligands

An efficient preparation of chiral 2,2?-bipyridines was developed. Compound 1 was synthesized in 54% yield for three steps starting from 2,6-dibromopyridine. In this synthesis, only catalytic amounts of metals were used in the asymmetric reduction and homo-coupling reaction steps. The total yield and simplicity of experimental procedures were much improved compared with those of the previous report. Other chiral 2,2?-bipyridines were similarly synthesized with high efficiency. Georg Thieme Verlag Stuttgart.

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Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

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4 – Aminopyridine derivatives, its pharmaceutical composition, preparation method and application (by machine translation)

The invention discloses a 4 – aminopyridine derivatives, preparation method thereof, pharmaceutical composition and application. The invention of 4 – aminopyridine derivative (I), an isomer, prodrug, stable isotope derivative or a pharmaceutically acceptable salt has the following structure. The invention of 4 – aminopyridine derivatives have good adenosine A2a receptor antagonism, can effectively treat or relieve the adenosine A2a receptor level disorders caused diseases, such as cancer, central nervous system diseases. (by machine translation)

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6-phenoxy picolinic acid alkylidene hydrazide derivative, process for producing the same and herbicide using the same

A 6-phenoxy picolinic acid alkylidene hydrazide derivative, a process for producing the derivative and a herbicide containing the derivative as an effective ingredient. Such a compound is a novel compound and is useful as an effective ingredient of herbicides.

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Cinnoline – Wikipedia,
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PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE HYDROXYMETHYLATED COMPOUNDS

The present invention presents a catalyst that allows asymmetric hydroxymethylation reactions to progress with excellent asymmetric selectivity and a production method for optically active hydroxymethylated compounds using the catalyst. Optically active hydroxymethylated compounds are obtained with excellent asymmetric selectivity by using a catalyst obtained by mixing chiral ligands (for example, chemical formula 4) with scandium triflate and the like.

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Modulation of helix stability of indolocarbazole-pyridine hybrid foldamers

Through variation of the central pyridine in an indolocarbazole-pyridine hybrid foldamer, the kinetic stabilities of helical conformations were determined and compared based on the inter-conversion rates of P and M helical isomers.

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Brief introduction of 875-66-1

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Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Gautheron Chapoulaud and a compound is mentioned, 875-66-1, Cinnolin-4-ol, introducing its new discovery. 875-66-1

Synthesis of 4,8-diarylcinnolines and quinazolines with potential applications in nonlinear optics. Diazines. Part 28

New 4,8-diarylbenzodiazines have been synthesized using cross-coupling reactions and regioselective metalation at the peri-position C8 of the benzene moiety of various cinnolines and quinazolines. Some of these compounds have been tested to assess their nonlinear optical properties. (C) 2000 Elsevier Science Ltd.

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Synthesis of N-benzyl-4-oxo-1,2,3,4-tetrahydrocinnolines

The method of preparation of N1 and N2-substituted 4-hydroxycinnolines by alkylation with benzyl bromide of the coresponding 4-hydroxycinnolines is described. The obtained derivatives were reduced to the corresponding N-benzyl-4-oxo-l,2,3,4-tetrahydrocinnolines. The effect of some synthesized derivatives on central nervous system was studied.

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ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

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Cinnoline – Wikipedia,
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ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

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Cinnoline – Wikipedia,
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Process for producing pyridinecarboxamides or thiocarboxamides

A process for producing N-substituted pyridine carboxamide or thiocarboxamide, comprising reacting a substituted or unsubstituted pyridine metal compound with substituted isocyanate or isothiocyanate to obtain an addition reaction product thereof, and then substituting the metal of said addition reaction product with a proton. The process according to the present invention can be applied even to compounds having an oxidation-susceptible substituent group and, therefore, industrially useful.

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Cinnoline – Wikipedia,
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