Category: 137195-33-6

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Acta Poloniae Pharmaceutica called Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline, Author is Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan, which mentions a compound: 137195-33-6, SMILESS is O=C1CNNC2=C1C=CC=C2.[H]Cl, Molecular C8H9ClN2O, Related Products of 137195-33-6.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides, published in 1989, which mentions a compound: 137195-33-6, mainly applied to oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro, Formula: C8H9ClN2O.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

Compounds in my other articles are similar to this one(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Formula: C8H9ClN2O, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan published an article about the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6,SMILESS:O=C1CNNC2=C1C=CC=C2.[H]Cl ).Related Products of 137195-33-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:137195-33-6) through the article.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

Although many compounds look similar to this compound(137195-33-6)Related Products of 137195-33-6, numerous studies have shown that this compound(SMILES:O=C1CNNC2=C1C=CC=C2.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ) is researched.Application of 137195-33-6.Groszkowski, Stefan; Stanczak, Andrzej published the article 《Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides》 about this compound( cas:137195-33-6 ) in Acta Poloniae Pharmaceutica. Keywords: oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro. Let’s learn more about this compound (cas:137195-33-6).

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

As far as I know, this compound(137195-33-6)Application of 137195-33-6 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride.They published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》 about this compound( cas:137195-33-6 ) in Pharmazie. Keywords: central nervous system cinnoline derivative preparation. We’ll tell you more about this compound (cas:137195-33-6).

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

As far as I know, this compound(137195-33-6)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Kwapiszewski, Wincenty; Stanczak, Andrezej; Groszkowski, Stefan published the article 《Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline》. Keywords: cinnolone tetrahydro haloacyl derivative.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

As far as I know, this compound(137195-33-6)Safety of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 137195-33-6, is researched, Molecular C8H9ClN2O, about Synthesis of new derivatives of 1,2,5-triazepino[1,2-a]cinnoline. II. Synthesis of haloacyl derivatives of 4-oxo-1,2,3,4-tetrahydrocinnoline, the main research direction is cinnolone tetrahydro haloacyl derivative.Synthetic Route of C8H9ClN2O.

Stirring 1,2,3,4-tetrahydrocinnolin-4-one (I) with BrCH2COCl (II) in H2O at 0° gave 76% III (X = Br, R = R1 = R2 = H). III (X = Cl, R1 = R2 = H; R = Cl, Me, MeO; R = R1 = H, R2 = Cl, Me; R = H, R1 = R2 = MeO) were prepared analogously in 49-74% yields from the appropriately substituted I and ClCH2COCl (IV). When I and II were refluxed 10 h in C6H6, diacetylation occurred to give 67% V (X = Br, R1 = R2 = H). V (X = Cl, R1 = R2 = MeO; R1 = H, R2 = Cl, Me) were prepared analogously. V (X = Cl, R1 = R2 = H) was obtained from the corresponding III and IV in the presence of Et3N. Refluxing I 10 h with ClCH2CH2COCl in C6H6 gave 54% VI, which was also obtained as a byproduct when a similar reaction was carried out at 0° in CHCl3; the main product (60% yield) was 2-(3-chloropropionyl)-1,2,3,4-tetrahydrocinnolin-4-one.

As far as I know, this compound(137195-33-6)Synthetic Route of C8H9ClN2O can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

HPLC of Formula: 137195-33-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives. Author is Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W..

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

In addition to the literature in the link below, there is a lot of literature about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)HPLC of Formula: 137195-33-6, illustrating the importance and wide applicability of this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

Quality Control of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives.

Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.

In addition to the literature in the link below, there is a lot of literature about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Quality Control of 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, illustrating the importance and wide applicability of this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride, is researched, Molecular C8H9ClN2O, CAS is 137195-33-6, about Synthesis of new derivatives of [1,2,5]triazepino[1,2-a]cinnoline. I. Synthesis of 4-oxo-1,2,3,4-tetrahydrocinnoline hydrochlorides, the main research direction is oxotetrahydrocinnoline hydrochloride; cinnoline oxotetrahydro.Category: cinnoline.

The title cinnolines (I, R1 = R3 = R4 = H, R2 = H, Cl, Me; R1 = R2 = R3 = H, R4 = Cl, Me, OMe; R1 = R4 = H, R2 = R3 = OMe; R2 = R3 = R4 = H, R1 = Cl) were prepared by reduction of appropriately substituted 4-hydroxycinnlines (70-80% yields) and 4-hydroxy-3-cinnolinecarboxylic acids (55-67% yields) with Zn dust in AcOH-EtOH.

In addition to the literature in the link below, there is a lot of literature about this compound(2,3-Dihydrocinnolin-4(1H)-one hydrochloride)Category: cinnoline, illustrating the importance and wide applicability of this compound(137195-33-6).

Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics