New downstream synthetic route of Methyl cinnoline-6-carboxylate

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of Methyl cinnoline-6-carboxylate,, you can also browse my other articles. Thank you very much for taking the time to read this article.

The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism., 318276-74-3318276-74-3, If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular. 318276-74-3, name is Methyl cinnoline-6-carboxylate. A new synthetic method of this compound is introduced below.

A solution of the compound from example 3d) (345 mg; 1.8 mmol.) in anhydrous tetrahydrofuran (20.0 mL) was cooled to 5 oC for the portionwise addition of solid lithium aluminumhydride (70.0 mg; 1.8 mmol.) and stirred at 5 0C for 1 h. The mixture was quenched by the addition of ethyl acetate (50.0 mL) then water (5.0 mL), filtered through a pad of Celite and evaporated. The residue was dissolved in ethyl acetate (50.0 mL) and treated with manganese dioxide (0.50 g) and stirred at room temperature for 2 h. The mixture was filtered through a pad of Celite and evaporated to afford the title EPO compound (169 mg; 60%) as a brown powder which was used directly in the following step without further purification,

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of Methyl cinnoline-6-carboxylate,, you can also browse my other articles. Thank you very much for taking the time to read this article.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/38331; (2007); A2;,
Cinnoline – Wikipedia
Cinnoline – an overview | ScienceDirect Topics