Stanczak, A.; Kwapiszewski, W.; Szadowska, A.; Pakulska, W. published the article 《Synthesis and action on the central nervous system of some N2-substituted cinnoline derivatives》. Keywords: central nervous system cinnoline derivative preparation.They researched the compound: 2,3-Dihydrocinnolin-4(1H)-one hydrochloride( cas:137195-33-6 ).Formula: C8H9ClN2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:137195-33-6) here.
Alkylation of 4-hydroxycinnolines using Et bromoacetate resulted in N2-substituted acetic acids. These acids were converted to esters and amides. Some of the obtained acids were reduced with zinc dust to give 4-oxo-1,2,3,4-tetrahydro-2-cinnolineacetic acids. Several of the compounds were tested for their effect on central nervous system.
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Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics