Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Beilstein Journal of Organic Chemistry called Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt, Author is Lucas, Tobias; Dietz, Jule-Philipp; Opatz, Till, which mentions a compound: 1416372-67-2, SMILESS is NC1=NC(C)=NC=C1F, Molecular C5H6FN3, Related Products of 1416372-67-2.
A synthesis of fluorinated pyrimidines I [R = H, OMe, Ph, etc.] under mild conditions from amidine hydrochlorides and potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
This literature about this compound(1416372-67-2)Related Products of 1416372-67-2has given us a lot of inspiration, and I hope that the research on this compound(5-Fluoro-2-methylpyrimidin-4-amine) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Cinnoline – Wikipedia,
Cinnoline – an overview | ScienceDirect Topics